Arizona Cardinals Vs. Cleveland Browns Picks, Predictions: Who Wins NFL Week 6 Game?

The Arizona Cardinals and Cleveland Browns face off on Sunday in a Week 6 NFL game.

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Which team will get the victory?

Check out these NFL Week 6 picks and predictions for the game, which can be seen at 1:05 p.m. MST time on Fox.

Will Kyler Murray and the Arizona Cardinals beat the Cleveland Browns in Week 6 of the 2021 NFL season? © The Associated Press Will Kyler Murray and the Arizona Cardinals beat the Cleveland Browns in Week 6 of the 2021 NFL season?

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The Browns are a 2.5-point favorite in the game.

More NFL Week 6 picks, predictions:

More: NFL Week 6 picks, predictions: Who wins each Week 6 NFL game?

More: NFL playoff picture, standings, matchups after Week 5: Arizona Cardinals in pole position

Pro Football Network: Browns 34, Cardinals 30

Ben Rolfe writes: "This is a clash of two of the best teams in the NFL as the Cardinals look to stay unbeaten. Cleveland’s defense was exposed by the Chargers, but Arizona’s defense is also vulnerable. This should be a high-scoring NFL game and those are always tough to make picks and predictions for. The Browns need this one more at home and that could make all the difference."

More: NFL power rankings: Arizona Cardinals strengthen hold on No. 1 spot after Week 5 win

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Sportsnaut: Browns 31, Cardinals 24

Vincent Frank writes: "This could very well be a statement game for Arizona against a legitimate title contender. Baker Mayfield has a ton of weapons on offense. Cleveland’s defense is vastly improved from a season ago. That’s going to be the different in what promises to be a close game in Ohio."


Video: Rapoport: Cardinals 'not expecting' Chandler Jones to play vs. Browns (NFL)